Oligonucleotide Synthesis, Modification, and Purification Services Market Size is valued at USD 4.69 billion in 2024 and is predicted to reach USD 12.27 billion by the year 2034 at a 10.02% CAGR during the forecast period for 2025-2034.
Key Industry Insights & Findings from the Report:
Synthetic DNA oligonucleotides are applied in a wide range of applications, from fundamental research to clinical diagnostics and biotherapeutics. Oligonucleotides are chemically synthesized molecular chains from nucleosides. Solid-phase synthesis is the most popular method used for oligonucleotides chemical synthesis. They have a variety of uses in biology, biochemistry, molecular diagnostics, genomics, forensics, and others. Selecting the suitable oligonucleotide synthesizer for application is critical to optimizing product quality while maintaining cost-effectiveness.
The primary elements boosting the growth of the oligonucleotide synthesis, modification, and purification services market include increasing demand for oligonucleotides, growing preference of patients toward personalized medicines, rising collaborations and mergers/acquisitions by manufacturers, and growing older population, and the high prevalence of chronic diseases. Apart from this, the need for high-quality oligos is increasing due to the increase in R&D activities. Therefore, biotech and pharmaceutical companies' increasing research and development activities to treat various viral infections, chronic diseases, and genetic disorders are expected to fuel market growth over the forecast years.
For instance, in July 2017, Nitto Denko Avecia Inc. (Avecia) opened a new oligonucleotide API manufacturing facility in Milford, MA. The expansion has added 20,000 sq. ft. of manufacturing and office space at the site and provided CGMP oligonucleotide manufacturing capacity up to 1.8 mol, bringing the site capacity to 3.0 mol. Also, this expansion has helped Avecia's clients to receive timely oligonucleotide API to advance their drug development programs in clinical trials. However, the low-quality oligonucleotide sequences, lack of technical requirements, and the complexities associated with the oligonucleotide synthesis may hamper the market growth.
The Oligonucleotide Synthesis, Modification, and Purification Services Market is segmented into product, application, type, and end-users. By product, it includes primers, probes, and DNA oligos, such as molecular beacons, randomer oligos, and more specialized variants like unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) oligos, as well as other categories such as light-activated oligos and chimeric oligos. RNA oligos encompass single guide RNA (sgRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligos (ASO), sequencing primers, and aptamers. Applications include therapeutic uses for conditions like neurological disorders, rare diseases, and other medical conditions, alongside research applications in PCR, sequencing, and diagnostics. The market is further divided by types into customized oligos, predesigned oligos, reagents & consumables, and equipment. End-users span across hospitals, pharmaceutical and biotechnology companies, diagnostic laboratories, CROs and CMOs, and academic research institutes.
The market is being examined throughout North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa. Due to increased R&D investments in pharma and biotech businesses to enhance oligonucleotide production and synthesis processes, North America is likely to have the largest share of this market throughout the forecast years, followed by Europe.
| Report Attribute | Specifications |
| Market Size Value In 2024 | USD 4.69 Bn |
| Revenue Forecast In 2034 | USD 12.27 Bn |
| Growth Rate CAGR | CAGR of 10.02% from 2025 to 2034 |
| Quantitative Units | Representation of revenue in US$ Billion and CAGR from 2025 to 2034 |
| Historic Year | 2021 to 2024 |
| Forecast Year | 2025-2034 |
| Report Coverage | The forecast of revenue, the position of the company, the competitive market structure, growth prospects, and trends |
| Segments Covered | By Product, Application, Type, and End-User |
| Regional Scope | North America; Europe; Asia Pacific; Latin America; Middle East & Africa |
| Country Scope | U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico ; France; Italy; Spain; South Korea; South East Asia |
| Competitive Landscape | Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players |
| Customization Scope | Free customization report with the procurement of the report, Modifications to the regional and segment scope. Particular Geographic competitive landscape. |
| Pricing And Available Payment Methods | Explore pricing alternatives that are customized to your particular study requirements. |
Oligonucleotide Synthesis, Modification, and Purification Services Market- by Product
Oligonucleotide Synthesis, Modification, and Purification Services Market- Application
Oligonucleotide Synthesis, Modification, and Purification Services Market- Type
Oligonucleotide Synthesis, Modification, and Purification Services Market- End-users
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region,
North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country,
Chapter 1. Methodology and Scope
1.1. Research Methodology
1.2. Research Scope & Assumptions
Chapter 2. Executive Summary
Chapter 3. Global Oligonucleotide Synthesis, Modification, and Purification Services Market Snapshot
Chapter 4. Global Oligonucleotide Synthesis, Modification, and Purification Services Market Variables, Trends & Scope
4.1. Market Segmentation & Scope
4.2. Drivers
4.3. Challenges
4.4. Trends
4.5. Investment and Funding Analysis
4.6. Porter's Five Forces Analysis
4.7. Incremental Opportunity Analysis (US$ MN), 2024-2031
4.8. Global Oligonucleotide Synthesis, Modification, and Purification Services Market Penetration & Growth Prospect Mapping (US$ Mn), 2023-2031
4.9. Competitive Landscape & Market Share Analysis, By Key Player (2023)
4.10. Use/impact of AI on OLIGONUCLEOTIDE SYNTHESIS, MODIFICATION, AND PURIFICATION SERVICES MARKET Industry Trends
Chapter 5. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 1: By Product, Estimates & Trend Analysis
5.1. Market Share by Product, 2024 & 2034
5.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Product:
5.2.1. Primers
5.2.2. Probes
5.2.3. DNA Oligos
5.2.3.1. Molecular Beacons
5.2.3.2. Randomer Oligos
5.2.3.3. Unlocked nucleobase analog (UNA) and twisted intercalating nucleic acid (TINA) Oligos
5.2.3.4. Others (Light-activated Oligos, Chimeric Oligos and Trimers Mixes)
5.2.4. RNA Oligos
5.2.4.1. Single Guide RNA (sgRNA)
5.2.4.2. Small Interfering RNA (siRNA)
5.2.4.3. MicroRNA (miRNA)
5.2.4.4. Antisense Oligo (ASO)
5.2.4.5. Sequencing Primers
5.2.4.6. Aptamers
5.2.4.7. Others (Long RNA, etc.)
5.2.5. Others
Chapter 6. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 2: By Application, Estimates & Trend Analysis
6.1. Market Share by Application, 2024 & 2034
6.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Application:
6.2.1. Therapeutic Applications
6.2.1.1. Neurological Disorders
6.2.1.2. Rare Diseases
6.2.1.3. Other Diseases
6.2.2. Research Applications
6.2.2.1. PCR
6.2.2.2. Sequencing
6.2.2.3. Other Research Applications
6.2.3. Diagnostic Applications
Chapter 7. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 3: By Type, Estimates & Trend Analysis
7.1. Market Share by Type, 2024 & 2034
7.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following Type:
7.2.1. Customized Oligos
7.2.2. Predesigned Oligos
7.2.3. Reagents & Consumables
7.2.4. Equipment
Chapter 8. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 4: By End User, Estimates & Trend Analysis
8.1. Market Share by End User, 2024 & 2034
8.2. Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2021 to 2034 for the following End User:
8.2.1. Hospitals
8.2.2. Pharmaceutical & Biotechnology Companies
8.2.3. Diagnostic Laboratories
8.2.4. CROs and CMOs
8.2.5. Academic Research Institutes
Chapter 9. Oligonucleotide Synthesis, Modification, and Purification Services Market Segmentation 5: Regional Estimates & Trend Analysis
9.1. Global Oligonucleotide Synthesis, Modification, and Purification Services Market, Regional Snapshot 2024 & 2034
9.2. North America
9.2.1. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.2.1.1. US
9.2.1.2. Canada
9.2.2. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.2.3. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.2.4. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.2.5. North America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.3. Europe
9.3.1. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.3.1.1. Germany
9.3.1.2. U.K.
9.3.1.3. France
9.3.1.4. Italy
9.3.1.5. Spain
9.3.1.6. Rest of Europe
9.3.2. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.3.3. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.3.4. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.3.5. Europe Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.4. Asia Pacific
9.4.1. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.4.1.1. India
9.4.1.2. China
9.4.1.3. Japan
9.4.1.4. Australia
9.4.1.5. South Korea
9.4.1.6. Hong Kong
9.4.1.7. Southeast Asia
9.4.1.8. Rest of Asia Pacific
9.4.2. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.4.3. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.4.4. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts By Type, 2021-2034
9.4.5. Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.5. Latin America
9.5.1. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Country, 2021-2034
9.5.1.1. Brazil
9.5.1.2. Mexico
9.5.1.3. Rest of Latin America
9.5.2. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.5.3. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.5.4. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.5.5. Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
9.6. Middle East & Africa
9.6.1. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by country, 2021-2034
9.6.1.1. GCC Countries
9.6.1.2. Israel
9.6.1.3. South Africa
9.6.1.4. Rest of Middle East and Africa
9.6.2. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Product, 2021-2034
9.6.3. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Application, 2021-2034
9.6.4. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by Type, 2021-2034
9.6.5. Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market Revenue (US$ Million) Estimates and Forecasts by End User, 2021-2034
Chapter 10. Competitive Landscape
10.1. Major Mergers and Acquisitions/Strategic Alliances
10.2. Company Profiles
10.2.1. Agilent Technologies
10.2.1.1. Business Overview
10.2.1.2. Key Product/Service Type
10.2.1.3. Financial Performance
10.2.1.4. Geographical Presence
10.2.1.5. Recent Developments with Business Strategy
10.2.2. Ajinomoto Bio-Pharma Services
10.2.3. CordenPharma
10.2.4. Integrated DNA Technologies
10.2.5. Kaneka Eurogentec
10.2.6. LGC Biosearch Technologies
10.2.7. Microsynth
10.2.8. Merck KGaA
10.2.9. Nitto Avecia
10.2.10. Thermo Fisher Scientific
10.2.11. TriLink BioTechnologies
10.2.12. Creative Biolabs
10.2.13. Ella Biotech
10.2.14. Eurofins Scientific
10.2.15. Ribo Biotechnology
10.2.16. WuXi AppTec
10.2.17. GE Healthcare
10.2.18. Bio-synthesis Inc.
10.2.19. Almac Group
10.2.20. Sumitomo Chemical
10.2.21. BioSpring
10.2.22. ChemGenes
10.2.23. BianoScience GmbH
10.2.24. ATDBio Ltd
10.2.25. Burkert UK Limited
10.2.26. IBA Lifesciences GmbH
10.2.27. Other Market Players